Endocrine Abstracts

Traumatic thoracic injuries in children and adolescents are rare, but could be connected with others traumas, often with traumatic brain injury (TBI). Based on data in the current literature, approximately 15–20% of TBI patients develop chronic hypopituitarism. Growth hormone (GH) and ACTH deficiency are the most common, followed by gonadotropins and thyroid-stimulating hormone. The greatest challenge associated with endocrine complications in individuals with polytrauma ...

Objective: The management of pituitary tumors causing Cushing’s Disease are a multidisciplinary challenge to clinicians with neurosurgery as a first line treatment followed by the radiotherapy and pharmacotherapy including chemiotherapy.Such tumors are difficult to treat with high rate of recurrence. To date only 25 patients with Cushing Disease treated with the new alkylating agent temozolamide (TMZ) have been reported.Materials and methods: Sixty-...

Background: Familial Hyperinsulinaemic hypoglycaemia (FHH) is a very rare disease with heterogeneous clinical manifestation causing risk of late diagnosis or even misdiagnosis. In infants and children, it can lead to serious and permanent damage to the central nervous system. FHH has been correlated with mono-gene mutations in approximately 48% of cases. Clinical manifestation may vary even in the same affected GCK mutation family.Objective: To describe ...

Background: Despite increased awareness among cardiologists about the risk of amiodarone’s significant side effects, it is still a commonly used antiarrhythmic drug. Amiodarone may induced easy for management hypothyroidism which affect even 25% of patients or less frequent thyrotoxicosis (AIT) which causes a challenge for clinicians. Type 1 of AIT occurs on the basis of pre-existing thyroid diseases such as nodular goiter or latent Graves’ disease, type 2 results fr...